Blar i forfatter "Bandason, Tsitsi"

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    • Cytomegalovirus-SpecificImmunoglobulin G is associated with chronic lung disease in children and adolescents from sub-Saharan Africa with perinatal HIV infection 

      Bowen, Dan Hameiri; Sovershaeva, Evgeniya; Charlton, Bethany; Schive, Cecilie; Odland, Jon Øyvind; McHugh, Grace; Bandason, Tsitsi; Mayin, Justin; Ferrand, Rashida A.; Yindom, Louis-Marie; Rowland-Jones, Sara L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-26)
      In a cross-sectional study of 296 children and adolescents from Zimbabwe living with perinatal human immunodeficiency virus, individuals with the top tertile of cytomegalovirus-specific immunoglobulin G titer had an increased odds of chronic lung disease (odds ratio, 3.33; 95% confidence interval, 1.37–8.85; P = .010).

    • “The effect of 48-weeks azithromycin therapy on levels of soluble biomarkers associated with HIV-associated chronic lung disease” 

      Hameiri-Bowen, Dan; Yindom, Louis-Marie; Sovershaeva, Evgeniya; Bandason, Tsitsi; Mayini, Justin; M Rehman, Andrea; Simms, Victoria; Gift Ngwira, Lucky; Flagestad, Trond; Gutteberg, Tore Jarl; McHugh, Grace; Abbas Ferrand, Rashida; Rowland-Jones, Sarah L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-20)
      Objectives - HIV-associated immune activation contributes to chronic lung disease (CLD) in children and adolescents living with HIV. Azithromycin has immunomodulatory and anti-microbial properties that may be useful for treating HIV-associated CLD (HCLD). This study describes the effect of azithromycin on expression of plasma soluble biomarkers in children and adolescents with HCLD.<p> <p>Methods ...

    • The effect of azithromycin for management of HIV-associated chronic lung disease on right heart function: Results from the BREATHE trial 

      Majonga, Edith D.; Mapurisa, Gugulethu Newton; Rehman, Andrea M.; McHugh, Grace; Bandason, Tsitsi; Mujuru, Hilda; Gonzalez-Martinez, Carmen; Odland, Jon O.; Kennedy, Neil; Ferrand, Rashida A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-20)
      Background - Right heart abnormalities and pulmonary hypertension (PH) may be secondary to chronic lung disease. Chronic lung disease is common in children with HIV. In the BREATHE trial (Trial registration: NCT02426112), azithromycin (AZM) reduced the risk of acute respiratory exacerbations in children aged 6–19 years with HIV-associated chronic lung disease (HCLD) taking antiretroviral therapy. ...

    • Effect of azithromycin on incidence of acute respiratory exacerbations in children with HIV taking antiretroviral therapy and co-morbid chronic lung disease: a secondary analysis of the BREATHE trial 

      Price, Amy; McHugh, Grace; Simms, Victoria; Semphere, Robina; Ngwira, Lucky G; Bandason, Tsitsi; Mujuru, Hilda; Odland, Jon O; Ferrand, Rashida A; Rehman, Andrea M (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-13)
      Background - In the BREATHE trial weekly azithromycin decreased the rate of acute respiratory exacerbations (AREs) compared to placebo among children and adolescents with HIV-associated chronic lung disease (CLD) taking antiretroviral therapy (ART). The aim of this analysis was to identify risk factors associated with AREs and mediators of the effect of azithromycin on AREs.<p> <p>Methods - The ...

    • Exhaled nitric oxide is associated with inflammatory biomarkers and risk of acute respiratory exacerbations in children with HIV-associated chronic lung disease 

      Flygel, Trym Thune; Hameiri-Bowen, Dan; Simms, Victoria; Rowland-Jones, Sarah; Ferrand, Rashida Abbas; Bandason, Tsitsi; Yindom, Louis-Marie; Odland, Jon Øyvind; Cavanagh, Jorunn Pauline; Flægstad, Trond; Sovershaeva, Evgeniya (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-07)
      Objectives: Chronic lung disease is a recognized complication in children with HIV. Acute respiratory exacerbations (ARE) are common among this group and cause significant morbidity. Exhaled nitric oxide (eNO) is a known marker of local airway inflammation. We investigated the association between eNO and ARE, biomarkers of systemic inflammation, and the effect of azithromycin on eNO levels.<p> ...

    • History of tuberculosis is associated with lower exhaled nitric oxide levels in HIV-infected children 

      Sovershaeva, Evgeniya; Kranzer, Katharina; McHugh, Grace; Bandason, Tsitsi; Majonga, Edith D.; Usmani, Omar S.; Rowland-Jones, Sarah; Gutteberg, Tore Jarl; Flægstad, Trond; Ferrand, Rashida A.; Odland, Jon Øyvind (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-01)
      <p><i>Objective - </i>HIV disrupts host defense mechanisms and maintains chronic inflammation in the lung. Nitric oxide is a marker of lung inflammation and can be measured in the exhaled air. We investigated the relationship between exhaled nitric oxide (eNO), HIV status and airway abnormalities in perinatally HIV-infected children aged 6–19 years. <p><i>Design - </i>A cross-sectional study. <p ...

    • Patterns of detectable viraemia among children and adults with HIV infection taking antiretroviral therapy in Zimbabwe 

      Sovershaeva, Evgeniya; Shamu, Tinei; Wilsgaard, Tom; Bandason, Tsitsi; Flægstad, Trond; Katzenstein, David; Ferrand, Rashida A.; Odland, Jon Øyvind (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-31)
      <i>Objective</i>: To investigate the incidence and predictors of viraemia among individuals on antiretroviral therapy (ART) in Harare, Zimbabwe.<p> <p><i>Methods</i>: Children (0–19 years) and adults (>19 years) starting ART between 2013 and 2015 were followed for a median of 2.8 and 2.7 years, respectively. The incidence rates of virological failure (VF), low-level viraemia (LLV), and viral ...